TWEAK Polyclonal Antibody
簡(jiǎn)要描述：TWEAK Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應(yīng)性: Human;Mouse應(yīng)用: WB;IHC;IF;ELISA
產(chǎn)品型號(hào)： YP-Ab-00546
所屬分類：多克隆抗體
更新時(shí)間：2024-11-01
詳細(xì)說(shuō)明：
TWEAK Polyclonal Antibody
抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的。抗體以一個(gè)或者多個(gè)Y字形單體存在，每個(gè)Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來(lái)命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個(gè)抗體的重鏈則決定了它的類或型。
產(chǎn)品詳情
TWEAK Polyclonal Antibody detects endogenous levels of TWEAK protein.
免疫原詳細(xì)信息
The antiserum was produced against synthesized peptide derived from human TNFSF12. AA range:41-90
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
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備注：圖片僅供參考。僅供科研，不可用于臨床。
