VHL Polyclonal Antibody
簡要描述:VHL Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應性: Human;Mouse;Rat應用: IHC;IF;ELISA
產品型號: YP-Ab-00548
所屬分類:多克隆抗體
更新時間:2024-11-01
詳細說明:
VHL Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),是一種能特異性結合抗原的糖蛋白,而抗原是在易感染動物體內引發抗體產生的物質。在體內,抗體是由于外源性分子的侵襲而產生的。抗體以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區,為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結構上的差異),每一個抗體的重鏈則決定了它的類或型。
產品詳情
VHL Polyclonal Antibody detects endogenous levels of VHL protein.
免疫原詳細信息
The antiserum was produced against synthesized peptide derived from human VHL. AA range:34-83
相關試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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備注:圖片僅供參考。僅供科研,不可用于臨床。