MDM2 Polyclonal Antibody
簡要描述:MDM2 Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應(yīng)性: Human;Rat;Mouse;應(yīng)用: IF;WB;IHC;ELISA
產(chǎn)品型號: YP-Ab-00569
所屬分類:多克隆抗體
更新時間:2024-10-31
詳細(xì)說明:
MDM2 Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),是一種能特異性結(jié)合抗原的糖蛋白,而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi),抗體是由于外源性分子的侵襲而產(chǎn)生的。抗體以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),每一個抗體的重鏈則決定了它的類或型。
產(chǎn)品詳情
MDM2 Polyclonal Antibody detects endogenous levels of MDM2 protein.
免疫原詳細(xì)信息
The antiserum was produced against synthesized peptide derived from the C-terminal region of human MDM2. AA range:381-430
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
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備注:圖片僅供參考。僅供科研,不可用于臨床。